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Combined Role of Seizure-Induced Dendritic Morphology Alterations and Spine Loss in Newborn Granule Cells with Mossy Fiber Sprouting on the Hyperexcitability of a Computer Model of the Dentate Gyrus

Temporal lobe epilepsy strongly affects hippocampal dentate gyrus granule cells morphology. These cells exhibit seizure-induced anatomical alterations including mossy fiber sprouting, changes in the apical and basal dendritic tree and suffer substantial dendritic spine loss. The effect of some of th...

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Bibliografski detalji
Glavni autori: Tejada, Julian, Garcia-Cairasco, Norberto, Roque, Antonio C.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2014
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4014389/
https://ncbi.nlm.nih.gov/pubmed/24811867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1003601
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