Pitx2, an Atrial Fibrillation Predisposition Gene, Directly Regulates Ion Transport and Intercalated Disc Genes

BACKGROUND: Pitx2 is the homeobox gene located in proximity to the human 4q25 familial atrial fibrillation locus. When deleted in the mouse germline, Pitx2 haploinsufficiency predisposes to pacing induced atrial fibrillation indicating that reduced Pitx2 promotes an arrhythmogenic substrate. Previou...

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Bibliographic Details
Main Authors: Tao, Ye, Zhang, Min, Li, Lele, Bai, Yan, Zhou, Yuefang, Moon, Anne M., Kaminski, Henry J., Martin, James F.
Format: Artigo
Language:Inglês
Published: 2014
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4013500/
https://ncbi.nlm.nih.gov/pubmed/24395921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCGENETICS.113.000259
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