Cross-Protective Immunity to Leishmania amazonensis is Mediated by CD4+ and CD8+ Epitopes of Leishmania donovani Nucleoside Hydrolase Terminal Domains

The nucleoside hydrolase (NH) of Leishmania donovani (NH36) is a phylogenetic marker of high homology among Leishmania parasites. In mice and dog vaccination, NH36 induces a CD4+ T cell-driven protective response against Leishmania chagasi infection directed against its C-terminal domain (F3). The C...

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Dades bibliogràfiques
Autors principals: Nico, Dirlei, Gomes, Daniele Crespo, Alves-Silva, Marcus Vinícius, Freitas, Elisangela Oliveira, Morrot, Alexandre, Bahia, Diana, Palatnik, Marcos, Rodrigues, Mauricio M., Palatnik-de-Sousa, Clarisa B.
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2014
Matèries:
Immunology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4013483/
https://ncbi.nlm.nih.gov/pubmed/24822054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2014.00189
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