Identification and characterization of a drug sensitive strain enables puromycin-based translational assays in Saccharomyces cerevisiae

Puromycin is an aminonucleoside antibiotic with structural similarity to aminoacyl tRNA. This structure allows the drug to bind the ribosomal A-site and incorporate into nascent polypeptides causing chain termination, ribosomal subunit dissociation, and widespread translational arrest at high concen...

Full description

Saved in:
Bibliographic Details
Main Authors: Cary, Gregory A., Yoon, Sung Hwan, Torres, Cecilia Garmendia, Wang, Kathie, Hays, Michelle, Ludlow, Catherine, Goodlett, David R., Dudley, Aimée M.
Format: Artigo
Language:Inglês
Published: 2014
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4013229/
https://ncbi.nlm.nih.gov/pubmed/24610064
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/yea.3007
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items