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Identification and characterization of a drug sensitive strain enables puromycin-based translational assays in Saccharomyces cerevisiae
Puromycin is an aminonucleoside antibiotic with structural similarity to aminoacyl tRNA. This structure allows the drug to bind the ribosomal A-site and incorporate into nascent polypeptides causing chain termination, ribosomal subunit dissociation, and widespread translational arrest at high concen...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4013229/ https://ncbi.nlm.nih.gov/pubmed/24610064 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/yea.3007 |
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