Successful β cells islet regeneration in streptozotocin-induced diabetic baboons using ultrasound-targeted microbubble gene therapy with cyclinD2/CDK4/GLP1

Both major forms of diabetes mellitus (DM) involve β-cell destruction and dysfunction. New treatment strategies have focused on replenishing the deficiency of β-cell mass common to both major forms of diabetes by islet transplantation or β-cell regeneration. The pancreas, not the liver, is the ideal...

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Auteurs principaux: Chen, Shuyuan, Bastarrachea, Raul A, Roberts, Brad J, Voruganti, V Saroja, Frost, Patrice A, Nava-Gonzalez, Edna J, Arriaga-Cazares, Hector E, Chen, Jiaxi, Huang, Pintong, DeFronzo, Ralph A, Comuzzie, Anthony G, Grayburn, Paul A
Format: Artigo
Langue:Inglês
Publié: Landes Bioscience 2014
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4013164/
https://ncbi.nlm.nih.gov/pubmed/24553120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.27997
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