A Wide Range of 3243A>G/tRNALeu(UUR) (MELAS) Mutation Loads May Segregate in Offspring through the Female Germline Bottleneck

Segregation of mutant mtDNA in human tissues and through the germline is debated, with no consensus about the nature and size of the bottleneck hypothesized to explain rapid generational shifts in mutant loads. We investigated two maternal lineages with an apparently different inheritance pattern of...

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Bibliografiska uppgifter
Huvudupphovsmän: Pallotti, Francesco, Binelli, Giorgio, Fabbri, Raffaella, Valentino, Maria L., Vicenti, Rossella, Macciocca, Maria, Cevoli, Sabina, Baruzzi, Agostino, DiMauro, Salvatore, Carelli, Valerio
Materialtyp: Artigo
Språk:Inglês
Publicerad: Public Library of Science 2014
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4013013/
https://ncbi.nlm.nih.gov/pubmed/24805791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0096663
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