Simvastatin inhibited cardiac hypertrophy and fibrosis in apolipoprotein E-deficient mice fed a “Western-style diet” by increasing PPAR α and γ expression and reducing TC, MMP-9, and Cat S levels

AIM: The examine the cardiac hypertrophy and fibrosis in apolipoprotein E-deficient mice (ApoE−/− mice) fed a “Western-style diet” and the effect of simvastatin intervention. METHODS: Male ApoE−/− mice (n=36) were fed a “Western-style diet” from the age of 8 weeks. After 16 weeks, they were randomly...

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Main Authors: Qin, Yan-wen, Ye, Ping, He, Ji-qiang, Sheng, Li, Wang, Lu-ya, Du, Jie
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2010
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4012913/
https://ncbi.nlm.nih.gov/pubmed/20835264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2010.109
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