Mannan-binding lectin directly interacts with Toll-like receptor 4 and suppresses lipopolysaccharide-induced inflammatory cytokine secretion from THP-1 cells

Mannan-binding lectin (MBL) plays a key role in the lectin pathway of complement activation and can influence cytokine expression. Toll-like receptor 4 (TLR4) is expressed extensively and has been demonstrated to be involved in lipopolysaccharide (LPS)-induced signaling. We first sought to determine...

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Detalhes bibliográficos
Main Authors: Wang, Mingyong, Chen, Yue, Zhang, Yani, Zhang, Liyun, Lu, Xiao, Chen, Zhengliang
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4012877/
https://ncbi.nlm.nih.gov/pubmed/21383675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cmi.2011.1
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