TLR2 signaling subpathways regulate TLR9 signaling for the effective induction of IL-12 upon stimulation by heat-killed Brucella abortus

Brucella abortus is a Gram-negative intracellular bacterium that induces MyD88-dependent IL-12 production in dentritic cells (DCs) and a subsequent protective Th1 immune response. Previous studies have shown that the Toll-like receptor 2 (TLR2) is required for tumor-necrosis factor (TNF) production,...

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Detalhes bibliográficos
Main Authors: Zhang, Chun-Yan, Bai, Nan, Zhang, Zhu-Hong, Liang, Ning, Dong, Lan, Xiang, Rong, Liu, Cheng-Hu
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4012865/
https://ncbi.nlm.nih.gov/pubmed/22635254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cmi.2012.11
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