Chitinase 3-like 1 synergistically activates IL6-mediated STAT3 phosphorylation in intestinal epithelial cells in murine models of infectious colitis

BACKGROUND: Chitinase 3-like 1 (CHI3L1) is an inducible molecule on intestinal epithelial cells (IECs) during the development inflammatory bowel disease (IBD). METHODS: To investigate the role of CHI3L1 in bacterial infectious colitis, we orally inoculated pathogenic Salmonella typhimurium and poten...

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Autores principales: Tran, Hoa T., Lee, In-Ah, Low, Daren, Kamba, Alan, Mizoguchi, Atsushi, Shi, Hai Ning, Lee, Chun Geun, Elias, Jack A., Mizoguchi, Emiko
Formato: Artigo
Lenguaje:Inglês
Publicado: 2014
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4012618/
https://ncbi.nlm.nih.gov/pubmed/24694795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/MIB.0000000000000033
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