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Vascular variant of prion protein cerebral amyloidosis with tau-positive neurofibrillary tangles: the phenotype of the stop codon 145 mutation in PRNP.

Deposition of PrP amyloid in cerebral vessels in conjunction with neurofibrillary lesions is the neuropathologic hallmark of the dementia associated with a stop mutation at codon 145 of PRNP, the gene encoding the prion protein (PrP). In this disorder, the vascular amyloid in tissue sections and the...

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Published in:Proc Natl Acad Sci U S A
Main Authors: Ghetti, B, Piccardo, P, Spillantini, M G, Ichimiya, Y, Porro, M, Perini, F, Kitamoto, T, Tateishi, J, Seiler, C, Frangione, B, Bugiani, O, Giaccone, G, Prelli, F, Goedert, M, Dlouhy, S R, Tagliavini, F
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 1996
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Research Article
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC40125/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8570627/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.2.744
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