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A mutation in the insulin receptor gene that impairs transport of the receptor to the plasma membrane and causes insulin-resistant diabetes.

Insulin binds to a receptor on the cell surface, thereby triggering a biological response within the target cell. Mutations in the insulin receptor gene can render the cell resistant to the biological action of insulin. We have studied a family in which two sisters have a genetic form of insulin-res...

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Published in:EMBO J
Main Authors: Accili, D, Frapier, C, Mosthaf, L, McKeon, C, Elbein, S C, Permutt, M A, Ramos, E, Lander, E, Ullrich, A, Taylor, S I
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 1989
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Research Article
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC401244/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2573522/
https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1989.tb08388.x
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