Isoform-specific induction of actin reorganization by platelet-derived growth factor suggests that the functionally active receptor is a dimer.

Human platelet-derived growth factor (PDGF) occurs as three isoforms which are made up of disulfide-bonded A and B chains. The isoforms bind with different affinities to two different but structurally related cell surface receptors. The A type receptor binds all three isoforms (PDGF-AA, PDGF-AB, PDG...

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Bibliographische Detailangaben
Veröffentlicht in:EMBO J
Hauptverfasser: Hammacher, A, Mellström, K, Heldin, C H, Westermark, B
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 1989
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC401239/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2479551/
https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1989.tb08385.x
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