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Effect of the Brugada syndrome mutation A39V on calmodulin regulation of Cav1.2 channels
BACKGROUND: The L-type calcium channel Cav1.2 is important for brain and heart function. The ubiquitous calcium sensing protein calmodulin (CaM) regulates calcium dependent gating of Cav1.2 channels by reducing calcium influx, a process known as calcium-dependent inactivation (CDI). Dissecting the c...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4012176/ https://ncbi.nlm.nih.gov/pubmed/24775099 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1756-6606-7-34 |
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