Advantages of Papio anubis for preclinical testing of immunotoxicity of candidate therapeutic antagonist antibodies targeting CD28

Antagonist anti-CD28 antibodies prevent T-cell costimulation and are functionally different from CTLA4Ig since they cannot block CTLA-4 and PDL-1 co-inhibitory signals. They demonstrated preclinical efficacy in suppressing effector T cells while enhancing immunoregulatory mechanisms. Because a sever...

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Detalhes bibliográficos
Principais autores: Poirier, Nicolas, Mary, Caroline, Le Bas-Bernardet, Stephanie, Daguin, Veronique, Belarif, Lyssia, Chevalier, Melanie, Hervouet, Jeremy, Minault, David, Ville, Simon, Charpy, Vianney, Blancho, Gilles, Vanhove, Bernard
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2014
Assuntos:
Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4011914/
https://ncbi.nlm.nih.gov/pubmed/24598534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/mabs.28375
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