HCMV glycoprotein B is expressed in primary glioblastomas and enhances growth and invasiveness via PDGFR-alpha activation

Our laboratory first demonstrated that human cytomegalovirus (HCMV) is associated with the most deadly form of primary brain tumor, glioblastoma (GBM). We showed that HCMV glycoprotein B (gB) mediates viral cellular entry via the receptor tyrosine kinase PDGFR-alpha (PDGFRα), resulting in activation...

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Detalhes bibliográficos
Main Authors: Cobbs, Charles, Khan, Sabeena, Matlaf, Lisa, McAllister, Sean, Zider, Alex, Yount, Garret, Rahlin, Kenneth, Harkins, Lualhati, Bezrookove, Vladimir, Singer, Eric, Soroceanu, Liliana
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2014
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4011586/
https://ncbi.nlm.nih.gov/pubmed/24658280
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