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Clinical pharmacology considerations in biologics development

Biologics, including monoclonal antibodies (mAbs) and other therapeutic proteins such as cytokines and growth hormones, have unique characteristics compared to small molecules. This paper starts from an overview of the pharmacokinetics (PK) of biologics from a mechanistic perspective, the determinat...

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Detalhes bibliográficos
Main Authors: Zhao, Liang, Ren, Tian-hua, Wang, Diane D
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4011353/
https://ncbi.nlm.nih.gov/pubmed/23001474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2012.51
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