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Clinical pharmacology considerations in biologics development
Biologics, including monoclonal antibodies (mAbs) and other therapeutic proteins such as cytokines and growth hormones, have unique characteristics compared to small molecules. This paper starts from an overview of the pharmacokinetics (PK) of biologics from a mechanistic perspective, the determinat...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4011353/ https://ncbi.nlm.nih.gov/pubmed/23001474 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2012.51 |
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