Pharmacokinetic-pharmacodynamic modeling of diclofenac in normal and Freund's complete adjuvant-induced arthritic rats

AIM: To characterize pharmacokinetic-pharmacodynamic modeling of diclofenac in Freund's complete adjuvant (FCA)-induced arthritic rats using prostaglandin E(2) (PGE(2)) as a biomarker. METHODS: The pharmacokinetics of diclofenac was investigated using 20-day-old arthritic rats. PGE(2) level in...

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Detalhes bibliográficos
Main Authors: Zhang, Jing, Li, Pei, Guo, Hai-fang, Liu, Li, Liu, Xiao-dong
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4011350/
https://ncbi.nlm.nih.gov/pubmed/22842736
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2012.67
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