Human colorectal cancer-specific CCAT1-L lncRNA regulates long-range chromatin interactions at the MYC locus

The human 8q24 gene desert contains multiple enhancers that form tissue-specific long-range chromatin loops with the MYC oncogene, but how chromatin looping at the MYC locus is regulated remains poorly understood. Here we demonstrate that a long noncoding RNA (lncRNA), CCAT1-L, is transcribed specif...

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Detalhes bibliográficos
Main Authors: Xiang, Jian-Feng, Yin, Qing-Fei, Chen, Tian, Zhang, Yang, Zhang, Xiao-Ou, Wu, Zheng, Zhang, Shaofeng, Wang, Hai-Bin, Ge, Junhui, Lu, Xuhua, Yang, Li, Chen, Ling-Ling
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4011346/
https://ncbi.nlm.nih.gov/pubmed/24662484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2014.35
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