Phosphorylation of endothelial NOS contributes to simvastatin protection against myocardial no-reflow and infarction in reperfused swine hearts: partially via the PKA signaling pathway

AIM: The cholesterol-lowering drugs statins could enhance the activities of endothelial nitric oxide synthase (eNOS) and protect myocardium during ischemia and reperfusion. The aim of this study was to examine whether protein kinase A (PKA) was involved in statin-mediated eNOS phosphorylation and ca...

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Bibliographic Details
Main Authors: Li, Xiang-dong, Yang, Yue-jin, Geng, Yong-jian, Zhao, Jing-lin, Zhang, Hai-tao, Cheng, Yu-tong, Wu, Yi-ling
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2012
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4011153/
https://ncbi.nlm.nih.gov/pubmed/22659627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2012.27
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