Estradiol, but not testosterone, heightens cortisol-mediated negative feedback on pulsatile ACTH secretion and ACTH approximate entropy in unstressed older men and women

How sex steroids modulate glucocorticoid feedback on the hypothalamic-pituitary-corticotrope (HPC) unit is controversial in humans. We postulated that testosterone (T) in men and estradiol (E(2)) in women govern unstressed cortisol-mediated negative feedback on ACTH secretion. To test this hypothesi...

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Autores principales: Sharma, Animesh N., Aoun, Paul, Wigham, Jean R., Weist, Suanne M., Veldhuis, Johannes D.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Physiological Society 2014
Materias:
Translational Physiology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4010660/
https://ncbi.nlm.nih.gov/pubmed/24573184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpregu.00551.2013
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