Antioxidants Reduce Cellular and Functional Changes Induced by Intense Noise in the Inner Ear and Cochlear Nucleus

The present study marks the first evaluation of combined application of the antioxidant N-acetylcysteine (NAC) and the free radical spin trap reagent, disodium 2,4-disulfophenyl-N-tert-butylnitrone (HPN-07), as a therapeutic approach for noise-induced hearing loss (NIHL). Pharmacokinetic studies and...

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Main Authors: Lu, Jianzhong, Li, Wei, Du, Xiaoping, Ewert, Donald L., West, Matthew B., Stewart, Charles, Floyd, Robert A., Kopke, Richard D
Format: Artigo
Jezik:Inglês
Izdano: Springer US 2014
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4010594/
https://ncbi.nlm.nih.gov/pubmed/24497307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10162-014-0441-4
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