Imidazol-1-ylethylindazole Voltage-Gated Sodium Channel Ligands Are Neuroprotective during Optic Neuritis in a Mouse Model of Multiple Sclerosis

[Image: see text] A series of imidazol-1-ylethylindazole sodium channel ligands were developed and optimized for sodium channel inhibition and in vitro neuroprotective activity. The molecules exhibited displacement of a radiolabeled sodium channel ligand and selectivity for blockade of the inactivat...

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Detalhes bibliográficos
Main Authors: Browne, Lorcan, Lidster, Katie, Al-Izki, Sarah, Clutterbuck, Lisa, Posada, Cristina, Chan, A. W. Edith, Riddall, Dieter, Garthwaite, John, Baker, David, Selwood, David L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4010550/
https://ncbi.nlm.nih.gov/pubmed/24601592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm401881q
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