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Human Papillomavirus 16 Oncoprotein E7 Stimulates UBF1-Mediated rDNA Gene Transcription, Inhibiting a p53-Independent Activity of p14(ARF)
High-risk human papillomavirus oncoproteins E6 and E7 play a major role in HPV-related cancers. One of the main functions of E7 is the degradation of pRb, while E6 promotes the degradation of p53, inactivating the p14(ARF)-p53 pathway. pRb and p14(ARF) can repress ribosomal DNA (rDNA) transcription...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4010441/ https://ncbi.nlm.nih.gov/pubmed/24798431 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0096136 |
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