Biphasic regulation of P-glycoprotein function and expression by NO donors in Caco-2 cells

AIM: To investigate the effects of nitric oxide (NO) donors on the function and expression of P-glycoprotein (P-gp) in Caco-2 cells. METHODS: Caco-2 cells were exposed to NO donors for designated times. P-gp function and expression were assessed using Rhodamine123 uptake assay and Western blotting,...

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Detalhes bibliográficos
Main Authors: Duan, Ru, Hu, Nan, Liu, Hai-yan, Li, Jia, Guo, Hai-fang, Liu, Can, Liu, Li, Liu, Xiao-dong
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4010373/
https://ncbi.nlm.nih.gov/pubmed/22543702
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2012.25
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