Pharmacokinetic and pharmacodynamic profiles of recombinant human erythropoietin-loaded poly(lactic-co-glycolic acid) microspheres in rats

AIM: To characterize the pharmacokinetic and pharmacodynamic profiles of the recombinant human erythropoietin (rhEPO)-loaded poly(lactic-co-glycolic acid) (PLGA) microspheres in rats. METHODS: The rhEPO-loaded microspheres were prepared using a solid-in-oil-in-water emulsion method. Pharmacokinetics...

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Detalhes bibliográficos
Main Authors: Zhou, Xiang-lian, He, Jin-tian, Du, Hui-juan, Fan, Yang-yang, Wang, Ying, Zhang, Hong-xia, Jiang, Yang
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4010276/
https://ncbi.nlm.nih.gov/pubmed/22139004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2011.157
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