Differential involvement of GABA(A) and GABA(B) receptors in propofol self-administration in rats

AIM: Propofol has shown abuse potential. The aim of the present study is to investigate the effects of GABA(A) antagonist and GABA(B) agonist on propofol reinforcement. METHODS: Sprague-Dawley rats were trained to self-administer propofol at a dose of 1.7 mg/kg per infusion under a fixed ratio (FR1)...

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Detalhes bibliográficos
Main Authors: Yang, Bo, Wang, Ben-fu, Lai, Miao-jun, Zhang, Fu-qiang, Yang, Xiao-wei, Zhou, Wen-hua, Lian, Qing-quan
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4010203/
https://ncbi.nlm.nih.gov/pubmed/21986578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2011.123
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