An Evolutionarily Conserved Long Noncoding RNA TUNA Controls Pluripotency and Neural Lineage Commitment

SUMMARY: Here, we generated the first genome-scale shRNA library targeting lincRNAs in the mouse. We performed an unbiased loss-of-function study in mouse embryonic stem cells (mESCs) and identified 20 novel lincRNAs involved in the maintenance of pluripotency. Among these, TUNA (Tcl1 Upstream Neuro...

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Bibliografiske detaljer
Main Authors: Lin, Nianwei, Chang, Kung-Yen, Li, Zhonghan, Gates, Keith, Rana, Zacharia A., Dang, Jason, Zhang, Danhua, Han, Tianxu, Yang, Chao-Shun, Cunningham, Thomas J., Head, Steven R., Duester, Gregg, Dong, Duc, Rana, Tariq M.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4010157/
https://ncbi.nlm.nih.gov/pubmed/24530304
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2014.01.021
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