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Enhancer-targeted genome editing selectively blocks innate resistance to oncokinase inhibition
Thousands of putative enhancers are characterized in the human genome, yet few have been shown to have a functional role in cancer progression. Inhibiting oncokinases, such as EGFR, ALK, ERBB2, and BRAF, is a mainstay of current cancer therapy but is hindered by innate drug resistance mediated by up...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4009605/ https://ncbi.nlm.nih.gov/pubmed/24443471 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.166231.113 |
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