Mutations in 16S ribosomal RNA disrupt antibiotic--RNA interactions.

Two of six mutations at a base-paired site in Escherichia coli 16S rRNA confer resistance to nine different aminoglycoside antibiotics in vivo. Chemical probing of mutant and wild-type ribosomes in the presence of paromomycin indicates that interactions between the antibiotic and 16S rRNA in mutant...

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Bibliographic Details
Main Authors: De Stasio, E A, Moazed, D, Noller, H F, Dahlberg, A E
Format: Artigo
Language:Inglês
Published: 1989
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC400937/
https://ncbi.nlm.nih.gov/pubmed/2472961
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