The Relationship of Antibodies to Modified Citrullinated Vimentin and Markers of Bone and Cartilage Destruction in Rheumatoid Arthritis

Objective. To make individualised decisions regarding treatment is one of the most important challenges in clinical practise, and identification of sensitive and specific markers of prognosis is an important research question. The main objective of this study was to evaluate relationships between th...

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Main Authors:	Avdeeva, A. S., Aleksandrova, E. N., Novikov, A. A., Smirnov, A. V., Cherkasova, M. V., Nasonov, E. L.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Hindawi Publishing Corporation 2014
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.gov/pmc/articles/PMC4009265/ https://ncbi.nlm.nih.gov/pubmed/24839444 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2014/464585
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id	pubmed-4009265
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spelling	pubmed-40092652014-05-18 The Relationship of Antibodies to Modified Citrullinated Vimentin and Markers of Bone and Cartilage Destruction in Rheumatoid Arthritis Avdeeva, A. S. Aleksandrova, E. N. Novikov, A. A. Smirnov, A. V. Cherkasova, M. V. Nasonov, E. L. Int J Rheumatol Research Article Objective. To make individualised decisions regarding treatment is one of the most important challenges in clinical practise, and identification of sensitive and specific markers of prognosis is an important research question. The main objective of this study was to evaluate relationships between the level of autoantibodies, radiographic changes and laboratory markers of bone, and cartilage destruction. Methods. A total of 114 RA patients were examined. The serum concentration of IgM RF, antibodies to cyclic citrullinated peptide (anti-CCP), modified citrullinated vimentin (anti-MCV), matrix metalloproteinase 3 (MMP-3), and cartilage oligomeric matrix protein (COMP, ng/mL) were measured. The van der Heijde-modified Sharp Score was used to quantify the radiologic changes. Results. Among the patients who were high-positive for anti-MCV, the value of total modified Sharp score (mTSS) (96.5; 66–120) was higher as well as the joint space narrowing (82; 60.5–105.5), and a higher level of MMP-3 was recorded more frequently (56%) in comparison with negative/low-positive patients (57; 31–88, 50; 29–82, 31% resp., P < 0.05). The level of COMP was also higher among patients high-positive for anti-MCV (9.7; 8.1–13.1 and 6.8; 5.4–10.7, resp., P = 0.02). Conclusion. A high positive level of anti-MCV as contrasted with anti-CCP and IgM RF is associated with more pronounced destructive changes in the joints. Hindawi Publishing Corporation 2014 2014-04-15 /pmc/articles/PMC4009265/ /pubmed/24839444 http://dx.doi.org/10.1155/2014/464585 Text en Copyright © 2014 A. S. Avdeeva et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
institution	US NLM
collection	PubMed Central
language	Inglês
format	Artigo
topic	Research Article
spellingShingle	Research Article Avdeeva, A. S. Aleksandrova, E. N. Novikov, A. A. Smirnov, A. V. Cherkasova, M. V. Nasonov, E. L. The Relationship of Antibodies to Modified Citrullinated Vimentin and Markers of Bone and Cartilage Destruction in Rheumatoid Arthritis
description	Objective. To make individualised decisions regarding treatment is one of the most important challenges in clinical practise, and identification of sensitive and specific markers of prognosis is an important research question. The main objective of this study was to evaluate relationships between the level of autoantibodies, radiographic changes and laboratory markers of bone, and cartilage destruction. Methods. A total of 114 RA patients were examined. The serum concentration of IgM RF, antibodies to cyclic citrullinated peptide (anti-CCP), modified citrullinated vimentin (anti-MCV), matrix metalloproteinase 3 (MMP-3), and cartilage oligomeric matrix protein (COMP, ng/mL) were measured. The van der Heijde-modified Sharp Score was used to quantify the radiologic changes. Results. Among the patients who were high-positive for anti-MCV, the value of total modified Sharp score (mTSS) (96.5; 66–120) was higher as well as the joint space narrowing (82; 60.5–105.5), and a higher level of MMP-3 was recorded more frequently (56%) in comparison with negative/low-positive patients (57; 31–88, 50; 29–82, 31% resp., P < 0.05). The level of COMP was also higher among patients high-positive for anti-MCV (9.7; 8.1–13.1 and 6.8; 5.4–10.7, resp., P = 0.02). Conclusion. A high positive level of anti-MCV as contrasted with anti-CCP and IgM RF is associated with more pronounced destructive changes in the joints.
author	Avdeeva, A. S. Aleksandrova, E. N. Novikov, A. A. Smirnov, A. V. Cherkasova, M. V. Nasonov, E. L.
author_facet	Avdeeva, A. S. Aleksandrova, E. N. Novikov, A. A. Smirnov, A. V. Cherkasova, M. V. Nasonov, E. L.
author_sort	Avdeeva, A. S.
title	The Relationship of Antibodies to Modified Citrullinated Vimentin and Markers of Bone and Cartilage Destruction in Rheumatoid Arthritis
title_short	The Relationship of Antibodies to Modified Citrullinated Vimentin and Markers of Bone and Cartilage Destruction in Rheumatoid Arthritis
title_full	The Relationship of Antibodies to Modified Citrullinated Vimentin and Markers of Bone and Cartilage Destruction in Rheumatoid Arthritis
title_fullStr	The Relationship of Antibodies to Modified Citrullinated Vimentin and Markers of Bone and Cartilage Destruction in Rheumatoid Arthritis
title_full_unstemmed	The Relationship of Antibodies to Modified Citrullinated Vimentin and Markers of Bone and Cartilage Destruction in Rheumatoid Arthritis
title_sort	relationship of antibodies to modified citrullinated vimentin and markers of bone and cartilage destruction in rheumatoid arthritis
publisher	Hindawi Publishing Corporation
publishDate	2014
url	https://ncbi.nlm.nih.gov/pmc/articles/PMC4009265/ https://ncbi.nlm.nih.gov/pubmed/24839444 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2014/464585
_version_	1800409667045687296

The Relationship of Antibodies to Modified Citrullinated Vimentin and Markers of Bone and Cartilage Destruction in Rheumatoid Arthritis

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