HIV-1 Vpr Induces Adipose Dysfunction in Vivo Through Reciprocal Effects on PPAR/GR Co-Regulation

Viral infections, such as HIV, have been linked to obesity, but mechanistic evidence that they cause adipose dysfunction in vivo is lacking. We investigated a pathogenic role for the HIV-1 accessory protein viral protein R (Vpr), which can coactivate the glucocorticoid receptor (GR) and co-repress p...

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Autori principali: Agarwal, Neeti, Iyer, Dinakar, Patel, Sanjeet G., Sekhar, Rajagopal V., Phillips, Terry M., Schubert, Ulrich, Oplt, Toni, Buras, Eric D., Samson, Susan L., Couturier, Jacob, Lewis, Dorothy E., Rodriguez-Barradas, Maria C., Jahoor, Farook, Kino, Tomoshige, Kopp, Jeffrey B., Balasubramanyam, Ashok
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4009012/
https://ncbi.nlm.nih.gov/pubmed/24285483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3007148
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