Pro-Inflammatory Interleukin-1 Genotypes Potentiate the Risk of Coronary Artery Disease and Cardiovascular Events Mediated by Oxidized Phospholipids and Lipoprotein (a)

OBJECTIVE: To assess the influence of pro-inflammatory IL-1 genotype status on the risk of CAD, defined as >50% diameter stenosis, and cardiovascular events mediated by OxPL and Lp(a). BACKGROUND: Oxidized phospholipids (OxPL) are pro-inflammatory, circulate on lipoprotein (a) [Lp(a)] and mediate...

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Main Authors: Tsimikas, Sotirios, Duff, Gordon W., Berger, Peter B., Rogus, John, Huttner, Kenneth, Clopton, Paul, Brilakis, Emmanuel, Kornman, Kenneth S, Witztum, Joseph L
Format: Artigo
Jezik:Inglês
Izdano: 2014
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4008715/
https://ncbi.nlm.nih.gov/pubmed/24530664
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jacc.2013.12.030
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