Targeted Expression of Mu-Opioid Receptors in a Subset of Striatal Direct-Pathway Neurons Restores Opiate Reward

Mu-Opioid Receptors (MOR) are necessary for the analgesic and addictive effects of opioids such as morphine, but the MOR-expressing neuronal populations that mediate the distinct opiate effects remain elusive. Here we devised a novel conditional BAC rescue strategy to show that mice with targeted MO...

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Detalhes bibliográficos
Main Authors: Cui, Yijun, Ostlund, Sean B., James, Alex, Park, Chang Sin, Ge, Weihong, Roberts, Kristofer W., Mittal, Nitish, Murphy, Niall P., Cepeda, Carlos, Kieffer, Brigitte L., Levine, Michael S., Jentsch, J. David, Walwyn, Wendy M., Sun, Yi E., Evans, Christopher J., Maidment, Nigel T., Yang, X. William
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4008330/
https://ncbi.nlm.nih.gov/pubmed/24413699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.3622
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