Pathways of Transport Protein Evolution: Recent Advances

We herein report recent advances in our understanding of transport protein evolution. The Drug-Metabolite Transporter (DMT) superfamily (TC# 2.A.7) arose from a 2TMS precursor to give 4TMS proteins which then added one and duplicated to give 10. The proposed pathway is 2 –> 4 –> 5 –> 10. Th...

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Main Authors: Lam, Vincent H., Lee, Jong-Hoon, Silverio, Abe, Chan, Henry, Gomolplitinant, Kenny M., Povolotsky, Tatyana L., Orlova, Ekaterina, Sun, Eric I., Welliver, Carl H., Saier, Milton H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4008129/
https://ncbi.nlm.nih.gov/pubmed/21194372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1515/BC.2011.018
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