NUP214-ABL1-mediated cell proliferation in T-cell acute lymphoblastic leukemia is dependent on the LCK kinase and various interacting proteins

The NUP214-ABL1 fusion protein is a constitutively active protein tyrosine kinase that is found in 6% of patients with T-cell acute lymphoblastic leukemia and that promotes proliferation and survival of T-lymphoblasts. Although NUP214-ABL1 is sensitive to ABL1 kinase inhibitors, development of resis...

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Main Authors: De Keersmaecker, Kim, Porcu, Michaël, Cox, Luk, Girardi, Tiziana, Vandepoel, Roel, de Beeck, Joyce Op, Gielen, Olga, Mentens, Nicole, Bennett, Keiryn L., Hantschel, Oliver
Formato: Artigo
Idioma:Inglês
Publicado em: Ferrata Storti Foundation 2014
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4007916/
https://ncbi.nlm.nih.gov/pubmed/23872305
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2013.088674
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