A chimeric EGF-R-neu proto-oncogene allows EGF to regulate neu tyrosine kinase and cell transformation.

The neu oncogene, characterized by Weinberg and colleagues, is a transforming gene found in ethylnitrosourea-induced rat neuro/glioblastomas; its human proto-oncogene homologue has been termed erbB2 or HER2 because of its close homology with the epidermal growth factor receptor (EGF-R) gene (c-erbB1...

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Pubblicato in:	EMBO J
Autori principali:	Lehväslaiho, H, Lehtola, L, Sistonen, L, Alitalo, K
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Nature Publishing Group 1989
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC400785/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2565807/ https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1989.tb03360.x
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