Deletion of an N-terminal regulatory domain of the c-abl tyrosine kinase activates its oncogenic potential.

Lignende værker

• The N-terminal domain of the non-receptor tyrosine kinase ABL confers protein instability and suppresses tumorigenesis
  af: Yan, Zhengwei, et al.
  Udgivet: (2020)
• Structural and functional dissection of the DH and PH domains of oncogenic Bcr-Abl tyrosine kinase
  af: Reckel, Sina, et al.
  Udgivet: (2017)
• Human trk oncogenes activated by point mutation, in-frame deletion, and duplication of the tyrosine kinase domain.
  af: Coulier, F, et al.
  Udgivet: (1990)
• Identification of N-Terminal Lobe Motifs that Determine the Kinase Activity of the Catalytic Domains and Regulatory Strategies of Src and Csk Protein Tyrosine Kinases
  af: Huang, Kezhen, et al.
  Udgivet: (2009)
• Tyrosine Phosphorylation in the SH3 Domain Disrupts Negative Regulatory Interactions within the c-Abl Kinase Core
  af: Chen, Shugui, et al.
  Udgivet: (2008)