Antidepressant- and anxiolytic effects of the novel melatonin agonist Neu-P11 in rodent models

AIM: To investigate the potential antidepressant and anxiolytic effects of Neu-P11, a novel melatonin agonist, in two models of depression in rats and a model of anxiety in mice. METHODS: In the learned helplessness test (LH), Neu-P11 or melatonin (25–100 mg/kg, ip) was administered to rats 2 h befo...

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Autores principales: Tian, Shao-wen, Laudon, Moshe, Han, Li, Gao, Jun, Huang, Fu-lian, Yang, Yu-feng, Deng, Hai-feng
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2010
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4007730/
https://ncbi.nlm.nih.gov/pubmed/20581849
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2010.80
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