A MicroRNA Processing Defect in Smokers' Macrophages Is Linked to SUMOylation of the Endonuclease DICER

Despite the fact that alveolar macrophages play an important role in smoking-related disease, little is known about what regulates their pathophysiologic phenotype. Evaluating smoker macrophages, we found significant down-regulation of multiple microRNAs (miRNAs). This work investigates the hypothes...

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Bibliographic Details
Main Authors: Gross, Thomas J., Powers, Linda S., Boudreau, Ryan L., Brink, Brandi, Reisetter, Anna, Goel, Khushboo, Gerke, Alicia K., Hassan, Ihab H., Monick, Martha M.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2014
Subjects:
Molecular Bases of Disease
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4007470/
https://ncbi.nlm.nih.gov/pubmed/24668803
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.565473
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