A Histidine-rich Linker Region in Peptidylglycine α-Amidating Monooxygenase Has the Properties of a pH Sensor

Decreasing luminal pH is thought to play a role in the entry of newly synthesized and endocytosed membrane proteins into secretory granules. The two catalytic domains of peptidylglycine α-amidating monooxygenase (PAM), a type I integral membrane protein, catalyze the sequential reactions that conver...

Full description

Saved in:
Bibliographic Details
Main Authors: Vishwanatha, Kurutihalli, Bäck, Nils, Mains, Richard E., Eipper, Betty A.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2014
Subjects:
Cell Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4007436/
https://ncbi.nlm.nih.gov/pubmed/24627494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.545947
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items