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Synthesis and evaluation of cholecystokinin trimers: A multivalent approach to pancreatic cancer detection and treatment

In the quest for novel tools for early detection and treatment of cancer, we propose the use of multimers targeting overexpressed receptors at the cancer cell surface. Indeed, multimers are prone to create multivalent interactions, more potent and specific than their corresponding monovalent version...

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Autors principals: Brabez, Nabila, Nguyen, Kevin L., Saunders, Kara, Lacy, Ryan, Xu, Liping, Gillies, Robert J., Lynch, Ronald M., Chassaing, Gerard, Lavielle, Solange, Hruby, Victor J.
Format: Artigo
Idioma:Inglês
Publicat: 2013
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4007200/
https://ncbi.nlm.nih.gov/pubmed/23489620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2013.02.022
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