Rosiglitazone sensitizes hepatocellular carcinoma cell lines to 5-fluorouracil antitumor activity through activation of the PPARγ signaling pathway

AIM: Resistance to 5-fluorouracil (5-FU) is a major cause of chemotherapy failure in advanced hepatocellular carcinoma (HCC).Rosiglitazone, a peroxisome proliferator-activated receptor γ (PPARγ) agonist, has a crucial role in growth inhibition and induction of apoptosis in several carcinoma cell lin...

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Bibliographische Detailangaben
Hauptverfasser: Cao, Liang-qi, Wang, Xiao-li, Wang, Qian, Xue, Ping, Jiao, Xing-yuan, Peng, He-ping, Lu, Hai-wu, Zheng, Qiang, Chen, Xi-lin, Huang, Xiao-hui, Fu, Xin-hui, Chen, Jing-song
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2009
Schlagworte:
Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4007181/
https://ncbi.nlm.nih.gov/pubmed/19684609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2009.119
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