Inhibition of Rho-Kinase Improves Erectile Function, Increases Nitric Oxide Signaling and Decreases Penile Apoptosis in a Rat Model of Cavernous Nerve Injury

PURPOSE: Bilateral cavernous nerve injury results in up-regulation of ROCK signaling in the penis. This is linked to erectile dysfunction in an animal model of post-prostatectomy erectile dysfunction. We evaluated whether daily treatment with the ROCK inhibitor Y-27632 (Tocris Bioscience, Ellisville...

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Hlavní autoři: Hannan, Johanna L., Albersen, Maarten, Kutlu, Omer, Gratzke, Christian, Stief, Christian G., Burnett, Arthur L., Lysiak, Jeffrey J., Hedlund, Petter, Bivalacqua, Trinity J.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4007006/
https://ncbi.nlm.nih.gov/pubmed/23021998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.juro.2012.09.104
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