Hepatitis C Virus Core Protein Inhibits Interferon Production by a Human Plasmacytoid Dendritic Cell Line and Dysregulates Interferon Regulatory Factor-7 and Signal Transducer and Activator of Transcription (STAT) 1 Protein Expression

Plasmacytoid Dendritic Cells (pDCs) represent a key immune cell population in the defense against viruses. pDCs detect viral pathogen associated molecular patterns (PAMPs) through pattern recognition receptors (PRR). PRR/PAMP interactions trigger signaling events that induce interferon (IFN) product...

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Detalhes bibliográficos
Main Authors: Stone, Amy E. L., Mitchell, Angela, Brownell, Jessica, Miklin, Daniel J., Golden-Mason, Lucy, Polyak, Stephen J., Gale, Michael J., Rosen, Hugo R.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4006833/
https://ncbi.nlm.nih.gov/pubmed/24788809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0095627
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