Erk1/2 Activity Promotes Chromatin Features and RNAPII Phosphorylation at Developmental Promoters in Mouse ESCs

Erk1/2 activation contributes to mouse ES cell pluripotency. We found a direct role of Erk1/2 in modulating chromatin features required for regulated developmental gene expression. Erk2 binds to specific DNA sequence motifs typically accessed by Jarid2 and PRC2. Negating Erk1/2 activation leads to i...

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Библиографические подробности
Главные авторы: Tee, Wee-Wei, Shen, Steven S., Oksuz, Ozgur, Narendra, Varun, Reinberg, Danny
Формат: Artigo
Язык:Inglês
Опубликовано: 2014
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4006806/
https://ncbi.nlm.nih.gov/pubmed/24529373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2014.01.009
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