RNA interference-mediated downregulation of Beclin1 attenuates cerebral ischemic injury in rats

AIM: To test the role of the Beclin 1-dependent autophagy pathway in brain damage during cerebral ischemia. METHODS: Focal cerebral ischemia was established in rats using a middle cerebral artery occlusion (MCAO) model. A lentiviral vector-associated RNA interference (RNAi) system was stereotaxicall...

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Autores principales: Zheng, Yong-qiu, Liu, Jian-xun, Li, Xin-zhi, Xu, Li, Xu, Yong-gang
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2009
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4006642/
https://ncbi.nlm.nih.gov/pubmed/19574998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2009.79
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