Transforming growth factor-β induces Cdk2 relocalization to the cytoplasm coincident with dephosphorylation of retinoblastoma tumor suppressor protein

BACKGROUND: The transforming growth factor-β (TGF-β) signaling pathway functions to prevent tumorigenesis, and loss of sensitivity to TGF-β-mediated cell cycle arrest is nearly ubiquitous among human cancers. Our previous studies demonstrated that rapamycin potentiates TGF-β-induced cell cycle arres...

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Bibliographic Details

Published in:	Breast Cancer Res
Main Authors:	Brown, Kimberly A, Roberts, Richard L, Arteaga, Carlos L, Law, Brian K
Format:	Artigo
Language:	Inglês
Published:	BMC 2004
Subjects:	Research Article
Online Access:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC400660/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14979923/ https://ncbi.nlm.nih.govhttps://doi.org/10.1186/bcr762
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