Increased Genomic Integrity of an Improved Protein-Based Mouse Induced Pluripotent Stem Cell Method Compared With Current Viral-Induced Strategies

It has recently been shown that genomic integrity (with respect to copy number variants [CNVs]) is compromised in human induced pluripotent stem cells (iPSCs) generated by viral-based ectopic expression of specific transcription factors (e.g., Oct4, Sox2, Klf4, and c-Myc). However, it is unclear how...

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Detalhes bibliográficos
Main Authors: Park, Hansoo, Kim, Dohoon, Kim, Chun-Hyung, Mills, Ryan E., Chang, Mi-Yoon, Iskow, Rebecca Cheryl, Ko, Sanghyeok, Moon, Jung-Il, Choi, Hyun Woo, Man Yoo, Paulo Sng, Do, Jeong Tae, Han, Min-Joon, Lee, Eun Gyo, Jung, Joon Ki, Zhang, Chengsheng, Lanza, Robert, Kim, Kwang-Soo
Formato: Artigo
Idioma:Inglês
Publicado em: AlphaMed Press 2014
Assuntos:
Embryonic Stem Cells/Induced Pluripotent Stem (iPS) Cells
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4006484/
https://ncbi.nlm.nih.gov/pubmed/24763686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5966/sctm.2013-0149
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